Current Issue : January - March Volume : 2013 Issue Number : 1 Articles : 5 Articles
The current aim of our research work is to isolate the biomaterial from fruit pulp of Annona squamosa and evaluate its binding ability. The fruit pulp was subjected for isolating the biomaterial in a simplified and economic process. Using this biomaterial, granules were prepared taking diclofenac as a model drug. The granules were evaluated through various parameters like flowability, compressibility index, dispersibility, particle size, particle shape, hausner index, disintegration test, friability, angle of repose, bulk density and breaking strength. The research results revealed that the formulated granules using biomaterial show free flowing property with optimum breaking strength, significant dispersibility, and sufficient compressibility comparable to standard granules prepared using starch. Hence it can serve as novel potential biobinder for formulating tablets....
The performance of the novel chitin metal silicate (CMS) co-precipitates as a\r\nsingle multifunctional excipient in tablet formulation using direct compression and wet\r\ngranulation methods is evaluated. The neutral, acidic, and basic drugs Spironolactone\r\n(SPL), ibuprofen (IBU) and metronidazole (MET), respectively, were used as model drugs.\r\nCommercial Aldactone�®, Fleximex�® and Dumazole�® tablets containing SPL, IBU and\r\nMET, respectively, and tablets made using Avicel�® 200, were used in the study for\r\ncomparison purposes. Tablets of acceptable crushing strength (>40 N) were obtained using\r\nCMS. The friability values for all tablets were well below the maximum 1% USP tolerance\r\nlimit. CMS produced superdisintegrating tablets (disintegration time < 1 min) with the\r\nthree model drugs. Regarding the dissolution rate, the sequence was as follow:\r\nCMS > Fleximex�® > Avicel�® 200, CMS > Avicel�® 200 > Dumazole�® and Aldactone�® >\r\nAvicel�® 200 > CMS for IBU, MET and SPL, respectively. Compressional properties of\r\nformulations were analyzed using density measurements and the compression Kawakita\r\nequation as assessment parameters. On the basis of DSC results, CMS co precipitates were\r\nfound to be compatible with the tested drugs. Conclusively, the CMS co-precipitates have the potential to be used as filler, binder, and superdisintegrant, all-in-one, in the design of\r\ntablets by the direct compression as well as wet granulation methods....
Drug dosage forms contain many components in addition to the active\r\npharmaceutical ingredient(s) to assist in the manufacturing process as well as to optimise\r\ndrug delivery. Due to advances in drug delivery technology, excipients are currently\r\nincluded in novel dosage forms to fulfil specific functions and in some cases they directly\r\nor indirectly influence the extent and/or rate of drug release and absorption. Since plant\r\npolysaccharides comply with many requirements expected of pharmaceutical excipients\r\nsuch as non-toxicity, stability, availability and renewability they are extensively\r\ninvestigated for use in the development of solid oral dosage forms. Furthermore,\r\npolysaccharides with varying physicochemical properties can be extracted from plants at\r\nrelatively low cost and can be chemically modified to suit specific needs. As an example,\r\nmany polysaccharide-rich plant materials are successfully used as matrix formers in\r\nmodified release dosage forms. Some natural polysaccharides have even shown\r\nenvironmental-responsive gelation characteristics with the potential to control drug release\r\naccording to specific therapeutic needs. This review discusses some of the most important\r\nplant-derived polymeric compounds that are used or investigated as excipients in drug\r\ndelivery systems....
Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM)\r\nstarburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently,\r\nsmall interfering RNA (siRNA) complex with -CyD-containing polycations (CDP) having\r\nadamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment\r\nof solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical\r\napplications, including the interaction and intracellular delivery of DNA and RNA. The\r\npresent review will address the latest developments in dendrimer conjugates with\r\ncyclodextrins for siRNA delivery including the novel sustained release system....
The main objectives of our study were to prepare and evaluate a biodegradable nanoparticulate system of\r\nLetrozole (LTZ) intended for breast cancer therapy. LTZ loaded thiolated chitosan (TCS) nanoparticles were prepared\r\nby emulsion-solvent evaporation method. LTZ loaded TCS nanoaprticles were characterized by infrared spectra, drug\r\nentrapment efficiency and in vitro release. The system sustained release of LTZ significantly and further investigation\r\ncould exhibit its potential usefulness in breast cancer therapy. The nanoparticles of LTZ prepared from TCS - may\r\nrepresent a useful approach for targeting its release at its site of absorption, sustaining its release....
Loading....